UPM Institutional Repository

Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats


Citation

Khaled, M. A. and Abu, Jalila and Hashim, Kalthum and Mohamed Mustapha, Noordin and Saleh, W. Asma (2014) Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats. Research Journal of Biological Sciences, 9 (2). pp. 57-61. ISSN 1815-8846; ESSN: 1993-6087

Abstract

About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate film with therapeutic ultrasound. On application, the collagen-calcium alginate film with therapeutic ultrasound was well accepted by the animals without any adverse reaction. Mean percentage of wound contraction were significantly better in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium alginate film with therapeutic ultrasound treated group as compared to the other groups. Collagen is a biocompatible protein that does not interfere with the body’s normal immunologic response and can be used in non-healing chronic wounds which require a trigger to stimulate the normal healing process. In extensive wounds when there is lack of autologous tissue, biomaterials like collagen-calcium alginate may be beneficial and can be used.


Download File

[img]
Preview
PDF (Abstract)
Collagen.pdf

Download (183kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.3923/rjbsci.2014.57.61
Publisher: Medwell Journals
Keywords: Ultrasound; Collagen; Calcium alginate; Wound; Biomaterials; Tissues
Depositing User: Nabilah Mustapa
Date Deposited: 24 May 2015 03:54
Last Modified: 21 Nov 2016 05:00
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/rjbsci.2014.57.61
URI: http://psasir.upm.edu.my/id/eprint/36808
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item