Simple Search:

Chemopreventive activity of methanol extract of Melastoma malabathricum leaves in DMBA-induced mouse skin carcinogenesis


Citation

Ooi, Samuel Kah Kooi and Cheah, Yee Ling and Rodzi, Roihanah and Othman, Fezah and Mohtaruddin, Nurhafizah and Suhaili, Zarizal and Zakaria, Zainul Amiruddin (2014) Chemopreventive activity of methanol extract of Melastoma malabathricum leaves in DMBA-induced mouse skin carcinogenesis. African Journal of Traditional, Complementary and Alternative Medicines, 11 (4). pp. 66-70. ISSN 0189-6016; ESSN: 2505-0044

Abstract / Synopsis

Background: Melastoma malabathricum L. Smith (family Melastomaceae) is a shrub that has been used by the Malay practitioners of traditional medicine to treat various types of ailments. The present study aimed to determine the chemopreventive activity of methanol extract of M. malabathricum leaves (MEMM) using the standard 7,12-dimethylbenz(α)anthracene (DMBA)/croton oil-induced mouse skin carcinogenesis model. Materials and Methods: In the initiation phase, the mice received a single dose of 100µl/100 µg DMBA (group I-V) or 100µl acetone (group VI) topically on the dorsal shaved skin area followed by the promotion phase involving treatment with the respective test solutions (100 μl of acetone, 10 mg/kg curcumin or MEMM (30, 100 and 300mg/kg)) for 30 min followed by the topical application of tumour promoter (100µl croton oil). Tumors were examined weekly and the experiment lasted for 15 weeks. Results: MEMM and curcumin significantly (p<0.05) reduced the tumour burden, tumour incidence and tumour volume, which were further supported by the histopathological findings. Conclusion: MEMM demonstrated chemoprevention possibly via its antioxidant and anti-inflammatory activities, and the action of flavonoids like quercitrin.


Download File

[img]
Preview
PDF (Abstract)
Chemopreventive activity of methanol extract of Melastoma malabathricum leaves in DMBA-induced mouse skin carcinogenesis.pdf

Download (52kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Halal Products Research Institute
Publisher: African Traditional, Herbal Medicine Supporters Initiative
Keywords: Melastomaceae; Skin cancer; Anti-carcinogenic activity
Depositing User: Nabilah Mustapa
Date Deposited: 05 Aug 2015 12:04
Last Modified: 21 Nov 2016 11:51
URI: http://psasir.upm.edu.my/id/eprint/36779
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item