Citation
Bayat, Saadi and Abd. Malek, Emilia and Mohd Yahaya, Normi and Salleh, Abu Bakar and Tejo, Bimo Ario and Abdul Rahman, Mohd Basyaruddin
(2014)
Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme.
Tetrahedron Letters, 55 (46).
pp. 6303-6306.
ISSN 0040-4039; ESSN: 1873-3581
Abstract
The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Science |
| DOI Number: | https://doi.org/10.1016/j.tetlet.2014.09.012 |
| Publisher: | Elsevier |
| Keywords: | Promiscuous enzymes; Aldo–ketoreductase; Asymmetric; Aldol reaction |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 25 Jun 2015 07:54 |
| Last Modified: | 20 Aug 2015 08:07 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.tetlet.2014.09.012 |
| URI: | http://psasir.upm.edu.my/id/eprint/36590 |
| Statistic Details: | View Download Statistic |
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