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Acute and subchronic oral toxicity of oil palm puree in Sprague–Dawley rats


Citation

Zainal, Zaida and Ong, Augustine and Choo, Yuen May and Chang, Sui Kiat and Abdul Rahim, Afiqah and Khaza'ai, Huzwah (2020) Acute and subchronic oral toxicity of oil palm puree in Sprague–Dawley rats. International Journal of Environmental Research and Public Health, 17 (10). art. no. 3404. pp. 1-18. ISSN 1661-7827; ESSN: 1660-4601

Abstract

Palm puree is rich in antioxidants and is produced via blending various proportions of mesocarp fibre and crude palm oil. The aim of this study was to assess the acute and subchronic toxicity of palm puree in male and female Sprague–Dawley rats. For the acute toxicity study, animals administered single palm-puree doses (2000 mg kg−1) by gavage were observed daily for 14 d. For the subchronic toxicity study, the rats were administered 500, 1000, or 2000 mg kg−1 palm puree daily for 28 d. We evaluated body and organ weights; performed haematological, biochemical, and histopathological analyses of blood and organ samples during and after treatment; and calculated the oral no-observed-adverse-effect level (NOAEL). The toxicity studies showed no signs of toxicity or mortality. The haematological, biochemical, and histopathological analyses and body and organ weights indicated no evidence of substantial toxicity at any dose of palm puree. The oral lethal dose and NOAEL for the palm puree were greater than 2000 mg kg−1 d−1 over 28 d. To the best of our knowledge, the present study is the first to confirm the safety of palm puree as a novel functional food. These encouraging results warrant further studies to elucidate its potential for pharmaceutical formulations.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/ijerph17103404
Publisher: MDPI
Keywords: Palm puree; Acute toxicity; Subchronic toxicity; No-observed-adverse-effect level (NOAEL); Histopathology; Lethal dose 50 (LD50)
Depositing User: Nabilah Mustapa
Date Deposited: 15 Jun 2020 08:40
Last Modified: 15 Jun 2020 08:40
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijerph17103404
URI: http://psasir.upm.edu.my/id/eprint/36544
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