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Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents


Citation

Rafiee-Moghaddam, Roshanak and Salimon, Jumat and Haron, Md. Jelas and Jahangirian, Hossein and Ismail, Mohd Halim Shah and Afsah-Hejri, Leili and Vafaei, Nazanin and Tayefehchamani, Yasamin (2014) Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents. Digest Journal of Nanomaterials and Biostructures, 9 (1). pp. 261-271. ISSN 1842-3582

Abstract

Hydroxamic acids, fatty hydroxamic acids and their metal complexes are known as compounds that have biological activity. They have been investigated as antimicrobial compounds and were applied as antibacterial and antifungal agents in pharmacy andpharmaceutical compounds. In this research, the methyl fatty hydroxamic acids (MFHAs) based on Jatrophacurcas seed oil and their metal complexes include the copper (II) methyl fatty hydroxamate (Cu-MFHs) and iron (III) methyl fatty hydroxamate (Fe-MFHs) were prepared and applied as anti microbial agents against the Escherichia coli (E. coli), Proteus vulgaris (P. vulgaris) andProteus mirabilis (P. mirabilis) as gramnegative bacteria; methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (S. epidermidis) as gram-positive bacteria ; Candida parapsilosis (C. parapsilosis) and Candida Albicans(C. Albicans) as yeast family of fungi. The results showed that the antimicrobial activity of MFHAs, Cu-MFHs and Fe-MFHs increase while their amounts increase. Also metal complexation of MFHAs caused the anti microbial activity arise and this activity is higher for complexation by Cu(II) compared to that of Fe(III). Comparing antimicrobial activity of MFHAs, Cu-MFHs andFe-MFHs based on Jatrophacurcas seed oil with several antibiotic drugs such as ampicillin, chloramphenicol, gentamicin streptomycin, tetracycline and nystatin against the mentioned microbial showed that the Cu-MFHs andFe-MFHs have very strong antimicrobial activity.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
Faculty of Food Science and Technology
Publisher: Academy of Romanian Scientists
Keywords: Antimicrobial agent; Methyl fatty hydroxamic acids; Copper methyl fatty hydroxamate; Iron (III) methyl fatty hydroxamate; Jatrophacurcas seed oil
Depositing User: Nabilah Mustapa
Date Deposited: 14 Aug 2015 12:01
Last Modified: 29 Oct 2015 07:32
URI: http://psasir.upm.edu.my/id/eprint/36515
Statistic Details: View Download Statistic

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