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AMD3100 protects from UV-induced skin cancer


Byrne, Scott N. and Sarchio, Seri Narti Edayu (2014) AMD3100 protects from UV-induced skin cancer. OncoImmunology, 3 (2). art. no. e27562. pp. 1-3. ISSN 2162-402X


Sunlight causes skin cancer by directly damaging DNA as well as by suppressing antitumor immune responses. A major mechanism whereby sunlight exerts immunosuppressive effects is by modulating the migration of chemokine (C-X-C motif) receptor 4 (CXCR4)-expressing dermal mast cells into and away from the skin. We have demonstrated the importance of this by showing that the systemic administration of the CXCR4 antagonist AMD3100 prevents sunlight-induced immunosuppression as well as the consequent carcinogenic response. Our results highlight the therapeutic potential of antagonizing CXCR4 signaling, especially in individuals who are at high risk of developing skin cancer.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.4161/onci.27562
Publisher: Taylor & Francis
Keywords: Chemokines; Mast cells; Skin cancer; Immunosuppression; Sunlight; Ultraviolet radiation
Depositing User: Nabilah Mustapa
Date Deposited: 20 Jun 2015 11:08
Last Modified: 21 Aug 2015 02:35
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4161/onci.27562
URI: http://psasir.upm.edu.my/id/eprint/36376
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