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Innovations in MDR therapy: essential oil applications


Yang, Shun Kai and Alhosani, Maryam Sultan and Lim, Erin Swee Hua and Akseer, Riaz and Abushelaibi, Aisha and Lai, Kok Song (2019) Innovations in MDR therapy: essential oil applications. In: 2019 Advances in Science and Engineering Technology International Conferences (ASET 2019), 26 Mar.-10 Apr. 2019, Dubai, United Arab Emirates. .


There are three common outcomes when testing the application of combinatory therapies for potential use in the clinical setting against multi-drug resistant (MDR) bacteria; whether synergistic, additive or antagonistic. Due to their relatively more favourable outcomes, antibiotics and adjuvant achieving synergism have been the primary focus in the development of therapeutics thus far; this has also resulted in less attention given to additive interactions, which may be equally effective. Hence, in this study, the authors investigated the effects of additivity using a representative combination model involving Cinnamomum verum (cinnamon bark) essential oil (CBO) and meropenem, a carbapenem class of antibiotics. Based on the zeta potential measurements, outer membrane permeability and scanning electron microscopy, synergistic and additive interactions of cinnamon bark oil (CBO) indicated comparable bacterial membrane disruption, alluding similar degrees of cell perturbations at the molecular level. Results from this study suggests that further investigations should be looked into for combinatorial therapeutic pairs achieving additive indices so as not to disqualify potentially useful alternatives in antibiotic therapy.

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1109/ICASET.2019.8714399
Publisher: IEEE
Keywords: Antimicrobial resistance; Multidrug resistance; Essential oils; Cinnamon bark oil; Meropenem; Klebsiella pneumoniae
Depositing User: Nabilah Mustapa
Date Deposited: 15 Jun 2020 07:49
Last Modified: 15 Jun 2020 07:49
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1109/ICASET.2019.8714399
URI: http://psasir.upm.edu.my/id/eprint/36315
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