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A report of six clinical cases of lowered blood cholesterol profile associated with supplementation with polypeptide K (Diabegard®), a polypeptide isolated from the seeds of Momordica charantia Linn


Citation

Yong, Yean Sirn and Lee, Cheng Lok and Ahmad, Zuraini and Abdullah, Muhammad Nazrul Hakim (2014) A report of six clinical cases of lowered blood cholesterol profile associated with supplementation with polypeptide K (Diabegard®), a polypeptide isolated from the seeds of Momordica charantia Linn. Tropical Journal of Pharmaceutical Research, 13 (9). pp. 1555-1560. ISSN 1596-5996; ESSN: 1596-9827

Abstract / Synopsis

Purpose: To assess six patients with Diabegard® supplementation with reference to cholesterol profiles. Methods: We report the clinical courses of six individuals taking Diabegard® supplementation at 60 and 120 mg/day for 8 weeks. Results: Patients had a maximum of 52.13 % reduction in low-density lipoprotein (LDL) cholesterol, 47.67 % reduction in triglycerides and 35.78 % reduction in total cholesterol (TC) within 8 weeks of Diabegard® supplementation. Interestingly, high-density lipoprotein (HDL) cholesterol increased by approximately 23.29 %. Patients also had reduced readings for C-reactive protein (CRP) and homocysteine (with maximum reduction of 81.58 % and 57.41 % respectively). In some patients, these parameters were elevated prior to supplementation. Conclusion: These results suggest that supplementation of Diabegard® will improve patients’ cholesterol profile by reduction of LDL and TC. Patients also expressed lower CRP and homocysteine indicating reduced inflammation and reduction of cardiovascular diseases (CVD) risk. However, patients taking this supplementation are advised to seek medical consultation in monitoring their cholesterol and other biochemical profile levels.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Halal Products Research Institute
Sport Academy
DOI Number: https://doi.org/10.4314/tjpr.v13i9.25
Publisher: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
Keywords: Hypocholesterolemia; Diabegard®; Momordica charantia; C-reactive protein; Inflammation; Cardiovascular disease
Depositing User: Nabilah Mustapa
Date Deposited: 25 Jun 2015 09:13
Last Modified: 23 Oct 2015 11:21
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4314/tjpr.v13i9.25
URI: http://psasir.upm.edu.my/id/eprint/36251
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