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A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis


Wan Sulaiman, Wan Aliaa and Hoo, Fan Kee and Basri, Hamidon and Hasan, Shariful and Mohd Sazlly Lim, Sazlyna and Foo, Yoke Loong and Ching, Siew Mooi and Vasudevan, Ramachandran and Mohamed, Mohd Hazmi and Hashim, Hasnur Zaman (2014) A rare case of acute psychosis as an isolated manifestation of extrapontine myelinolysis. British Journal of Medicine and Medical Research, 4 (18). pp. 3554-3560. ISSN 2231-0614


Aims and Background: Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are recognized as osmotic demyelination syndrome (ODS). ODS is pathologically characterized by non-inflammatory demyelination of several brain structures with sparing of axons. This condition is usually associated with overzealous correction of hyponatraemia. Acute psychosis as the sole clinical manifestation is extremely rare. Presentation of Case: Hence, we report an interesting case of a middle-aged man who was diagnosed with EPM, following rapid correction of hyponatraemia and subsequently developed acute psychosis. He made a good recovery with supportive treatment alone. Discussion and Conclusion: The possibility of psychosis as a manifestation of ODS, particularly in patients with recent correction of hyponatraemia. The rate of correction of plasma sodium level is the key point for preventing ODS and its complications.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Gerontology
DOI Number: https://doi.org/10.9734/BJMMR/2014/9615
Publisher: Sciencedomain International
Keywords: Osmotic demyelination syndrome; Extrapontine myelinolysis; Hyponatraemia; Psychosis
Depositing User: Nabilah Mustapa
Date Deposited: 25 Jun 2015 00:44
Last Modified: 09 Oct 2015 00:43
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.9734/BJMMR/2014/9615
URI: http://psasir.upm.edu.my/id/eprint/36246
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