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Vomiting in docetaxel chemotherapy: which to blame, dose or gene?


Jabir, Rafid and Ho, Gwo Fuang and Anuar, Muhammad Azrif and Stanslas, Johnson (2014) Vomiting in docetaxel chemotherapy: which to blame, dose or gene? Journal of the Federation of American Societies for Experimental Biology, 28 (1 suppl.655.4). ISSN 0892-6638; ESSN: 1530-6860


The adverse effects (AEs) of docetaxel are major limiting factors of its success in the battle against cancer. AEs can be hematological and non-hematological (nausea, vomiting, diarrhea, rash and mucositis). Eventually, the dose is often reduced or regimen is diverted. Single nucleotide polymorphisms (SNPs) of genes encoding for proteins involved in the transport of docetaxel (ABCB1 and SLCO1B3) could potentially cause accumulation of the drug and consequent AEs. Therefore, we investigated the association between the SNPs (ABCB1 3435CT and SLCO1B3 334TG) and docetaxel AEs in seventy five Malaysian breast cancer patients receiving docetaxel as a single agent chemotherapy at 90-100 mg/m2 and 75 mg/m2 in the adjuvant and metastatic settings, respectively. The SNPs were analyzed using PCR-RFLP technique followed by DNA sequencing of selected samples. The patients were Chinese 37 (49%), Malays 32 (43%) and Indians 6 (8%). We found no significant association between the doses given and development of vomiting. However, Indian patients having ABCB1 3435TT (mutant) had a significant association with the development of vomiting (p=0.03). The SNPs-AEs association is an essential step in the achievement of personalized docetaxel chemotherapy milestones.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Federation of American Societies for Experimental Biology
Keywords: Vomiting; Docetaxel chemotherapy; Dose; Gene
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 18 Feb 2016 00:57
Last Modified: 18 Feb 2016 00:57
URI: http://psasir.upm.edu.my/id/eprint/35998
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