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The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii


Ghafourian, Sobhan and Good, Liam and Sekawi, Zamberi and Awang Hamat, Rukman and Soheili, Sara and Sadeghifard, Nourkhoda and Neela, Vasantha Kumari (2014) The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii. Memorias do Instituto Oswaldo Cruz, 109 (4). pp. 502-505. ISSN 0074-0276; ESSN: 1678-8060


Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates. The aim of the current study was to screen for functional TA systems among clinical isolates of A. baumannii and to identify the systems' locations. For this purpose, we screened 85 A. baumannii isolates collected from different clinical sources for the presence of the mazEF, relBE and higBA TA genes. The results revealed that the genes coding for the mazEF TA system were commonly present in all clinical isolates of A. baumannii. Reverse transcriptase-polymerase chain reaction analysis showed that transcripts were produced in the clinical isolates. Our findings showed that TA genes are prevalent, harboured by chromosomes and transcribed within A. baumannii. Hence, activation of the toxin proteins in the mazEF TA system should be investigated further as an effective antibacterial strategy against this bacterium.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1590/0074-0276130601
Publisher: Instituto Oswaldo Cruz
Keywords: Toxin-antitoxin systems; Acinetobacter baumannii; Antibacterial target
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 05 Feb 2016 00:28
Last Modified: 05 Feb 2016 00:28
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1590/0074-0276130601
URI: http://psasir.upm.edu.my/id/eprint/35747
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