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Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic


Hussein-Al-Ali, Samer Hasan and El Zowalaty, Mohamed Ezzat and Hussein, Mohd. Zobir and Ismail, Maznah and Webster, Thomas Jay (2014) Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic. International Journal of Nanomedicine, 9 (1). pp. 549-557. ISSN 1176-9114; ESSN: 1178-2013


This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Advanced Technology
Institute of Bioscience
DOI Number: https://doi.org/10.2147/IJN.S53079
Publisher: Dove Medical Press
Keywords: Magnetic nanoparticles; Streptomycin; Nanoantibiotics; Chitosan; Release; Antimicrobial activity; Methicillin-resistant Staphylococcus aureus
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 18 Jan 2016 01:26
Last Modified: 18 Jan 2016 01:26
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S53079
URI: http://psasir.upm.edu.my/id/eprint/35585
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