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Recent advances in food biopeptides: production, biological functionalities and therapeutic applications


Saadi, Sami and Saari, Nazamid and Anwar, Farooq and Abdul Hamid, Azizah and Mohd Ghazali, Hasanah (2015) Recent advances in food biopeptides: production, biological functionalities and therapeutic applications. Biotechnology Advances, 33 (1). pp. 80-116. ISSN 0734-9750; ESSN: 1873-1899


The growing momentum of several common life-style diseases such as myocardial infarction, cardiovascular disorders, stroke, hypertension, diabetes, and atherosclerosis has become a serious global concern. Recent developments in the field of proteomics offering promising solutions to solving such health problems stimulates the uses of biopeptides as one of the therapeutic agents to alleviate disease-related risk factors. Functional peptides are typically produced from protein via enzymatic hydrolysis under in vitro or in vivo conditions using different kinds of proteolytic enzymes. An array of biological activities, including antioxidative, antihypertensive, antidiabetic and immunomodulating has been ascribed to different types of biopeptides derived from various food sources. In fact, biopeptides are nutritionally and functionally important for regulating some physiological functions in the body; however, these are yet to be extensively addressed with regard to their production through advance strategies, mechanisms of action and multiple biological functionalities. This review mainly focuses on recent biotechnological advances that are being made in the field of production in addition to covering the mode of action and biological activities, medicinal health functions and therapeutic applications of biopeptides. State-of-the-art strategies that can ameliorate the efficacy, bioavailability, and functionality of biopeptides along with their future prospects are likewise discussed.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1016/j.biotechadv.2014.12.003
Publisher: Elsevier
Keywords: Functional peptides; Enzymatic hydrolysis; Protein hydrolysates; Penetration routes; Peptides bioavailability; Multiple biological activities; Antioxidative; Antihypertensive; In vitro and in vivo assessments
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 31 Dec 2015 01:52
Last Modified: 01 Nov 2017 09:26
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.biotechadv.2014.12.003
URI: http://psasir.upm.edu.my/id/eprint/35168
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