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Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities


Tang, Sook Wah and Sukari, Mohd Aspollah and Neoh, Bee Keat and Yeap, Yunie Soon Yu and Abdul, Ahmad Bustamam and Kifli, Nurolaini and Ee, Gwendoline Cheng Lian (2014) Phytochemicals from Kaempferia angustifolia Rosc. and their cytotoxic and antimicrobial activities. BioMed Research International, 2014. art. no. 417674. pp. 1-6. ISSN 2314-6133; ESSN: 2314-6141


Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), sucrose, -sitosterol, and its glycoside (8). The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR). Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5 -lanosta-9(11), 25-dien-3 -ol (7), and -sitosterol-3-O- -D-glucopyranoside (8) from this plant species has never been reported previously. The spectroscopic data of (7) is firstly described in this paper. Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines. However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines. Similarly, none of the extracts or compounds showed activity in the antimicrobial testing.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2014/417674
Publisher: Hindawi Publishing Corporation
Keywords: Phytochemicals; Kaempferia; Herbs; Cytotoxic; Antimicrobial activities
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 24 Dec 2015 03:49
Last Modified: 24 Dec 2015 03:49
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/417674
URI: http://psasir.upm.edu.my/id/eprint/34940
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