UPM Institutional Repository

Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles


Mftah, Ae and Alhassan, Fatah H. and Al-Qubaisi, Mothanna Sadiq and El Zowalaty, Mohamed Ezzat and Webster, Thomas Jay and Sh-Eldin, Mohammed Ali and Abdullah, Rasedee and Yap, Taufiq Yun Hin and Rashid, Shah Samiur (2015) Physiochemical properties, cytotoxicty and antimicrobial activity of sulphated zirconia nano particles. International Journal of Nanomedicine, 10 (1). pp. 765-774. ISSN 1176-9114; ESSN: 1178-2013


Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications.

Download File

[img] PDF
Restricted to Repository staff only

Download (3MB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.2147/IJN.S66058
Publisher: Dove Medical Press
Keywords: Sulphated zirconia; Nanoparticles; Antimicrobial; Anticancer
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 24 Dec 2015 04:13
Last Modified: 28 Nov 2016 02:36
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S66058
URI: http://psasir.upm.edu.my/id/eprint/34938
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item