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Phage display creates innovative applications to combat hepatitis B virus


Tan, Wen Siang and Ho, Kok Lian (2014) Phage display creates innovative applications to combat hepatitis B virus. World Journal of Gastroenterology, 20 (33). pp. 11650-11670. ISSN 1007-9327; ESSN: 2219-2840


Hepatitis B virus (HBV) has killed countless lives in human history. The invention of HBV vaccines in the 20th century has reduced significantly the rate of the viral infection. However, currently there is no effective treatment for chronic HBV carriers. Newly emerging vaccine escape mutants and drug resistant strains have complicated the viral eradication program. The entire world is now facing a new threat of HBV and human immunodeficiency virus co-infection. Could phage display provide solutions to these life-threatening problems? This article reviews critically and comprehensively the innovative and potential applications of phage display in the development of vaccines, therapeutic agents, diagnostic reagents, as well as gene and drug delivery systems to combat HBV. The application of phage display in epitope mapping of HBV antigens is also discussed in detail. Although this review mainly focuses on HBV, the innovative applications of phage display could also be extended to other infectious diseases.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3748/wjg.v20.i33.11650
Publisher: Baishideng Publishing Group
Notes: WJG 20th anniversary special issues (9): hepatitis B virus
Keywords: Phage display; Hepatitis B virus; Epitope mapping; Drug delivery; Gene delivery; Antiviral drug; Therapeutics; Diagnosis; Hepatocellular carcinoma; Virus-like particle; Vaccine
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 23 Dec 2015 07:59
Last Modified: 31 Oct 2017 05:11
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3748/wjg.v20.i33.11650
URI: http://psasir.upm.edu.my/id/eprint/34893
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