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Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials


Rahman, Heshu Sulaiman and Abdullah, Rasedee and Yeap, Swee Keong and Othman, Hemn Hassan and Chartrand, Max Stanley and Namvar, Farideh and Abdul, Ahmad Bustamam and How, Chee Wun (2014) Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. BioMed Research International, 2014. art. no. 920742. pp. 1-20. ISSN 2314-6133; ESSN: 2314-6141


Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Institute of Bioscience
Institute of Tropical Forestry and Forest Products
DOI Number: https://doi.org/10.1155/2014/920742
Publisher: Hindawi Publishing Corporation
Keywords: Zerumbone; Anticancer bioactivity; Biomedical properties; Cancer chemopreventive
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 19 Sep 2016 09:52
Last Modified: 19 Sep 2016 09:52
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/920742
URI: http://psasir.upm.edu.my/id/eprint/34811
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