Mechanisms of action and efficacy of statins against influenza

Citation

Mehrbod, Parvaneh and Omar, Abdul Rahman and Bejo, Mohd Hair and Haghani, Amin and Ideris, Aini (2014) Mechanisms of action and efficacy of statins against influenza. BioMed Research International, 2014 . art. no. 872370. pp. 1-8. ISSN 2314-6133; ESSN: 2314-6141

Abstract

The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness.

Download File

PDF
Mechanisms of Action and Efficacy of Statins against Influenza.pdf
Restricted to Repository staff only
Download (2MB)

Official URL or Download Paper: http://www.hindawi.com/journals/bmri/2014/872370/a...

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Veterinary Medicine Institute of Bioscience
DOI Number:	https://doi.org/10.1155/2014/872370
Publisher:	Hindawi Publishing Corporation
Keywords:	Influenza; Influenza virus; Statins
Depositing User:	Nurul Ainie Mokhtar
Date Deposited:	15 Dec 2015 04:51
Last Modified:	15 Dec 2015 04:51
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2014/872370
URI:	http://psasir.upm.edu.my/id/eprint/34479
Statistic Details:	View Download Statistic

Actions (login required)

View Item