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Formation of high stability bio-inorganic materials: deoxyribonucleic acid (DNA) encapsulated in inorganic layered doubled hydroxide interlamella


Citation

Suyub, Iswan Budy and Hussein, Mohd Zobir and Mohd Yusoff, Khatijah (2005) Formation of high stability bio-inorganic materials: deoxyribonucleic acid (DNA) encapsulated in inorganic layered doubled hydroxide interlamella. In: International Advanced Technology Congress: Conference on Advanced Materials (CAM 2005), 6 - 8 Dec. 2005, Putrajaya, Malaysia. (pp. 340-350).

Abstract / Synopsis

Deoxyribonucleic acid (DNA) from salmon sperm was encapsulated into the inorganic Zn/Al-layered double hydroxides (LDHs) interlamellae for the formation of bio-inorganic nanohybrids materials (BINHs) by self-assembly method. Intercalation of DNA into Zn/Al-layered double hydroxides inorganic interlamellae host was carried out at different Zn/Al ratios, Rs and various concentrations of DNA. The physicochemical properties of the as-synthesized LDH and the resulting nanocomposite were studied using powder xray diffraction (PXRD) analysis. Expansion of basal spacing to about 21.2 Å (for R=3 and [DNA] = 100 mg/ml) and 21.9 Å (for R=1 and [DNA] = 44.4 mg/ml) in the resulting nanomaterials was observed compared to their respective LDHs with nitrate as counter ion with basal spacing of 9.0 Å and 8.9 Å. This confirmed the successful intercalation of DNA into the host-matrix, LDHs and the expansion observed is due to spatial orientation of the DNA in the LDH inorganic interlamellae.


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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Advanced Technology
Publisher: Universiti Putra Malaysia Press
Keywords: Bio-inorganic materials; Deoxyribonucleic acid (DNA); Inorganic layered doubled hydroxide; Interlamella
Depositing User: Erni Suraya Abdul Aziz
Date Deposited: 28 Apr 2015 16:56
Last Modified: 28 Apr 2015 16:56
URI: http://psasir.upm.edu.my/id/eprint/33863
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