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Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit


Citation

M.H., Nurulhuda and Azlan, Azrina and Ismail, Amin and Amom, Zulkhairi and Shakirin, Faridah Hanim (2012) Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit. In: 4th International Conference on Biomedical Engineering, 8-12 Jan 2012, Ho Chi Minh, Vietnam. (pp. 141-144).

Abstract

‘Sibu olive’ is known botanically as "Canarium Odontophyllum Miq." The present study was designed to assess the effect of Sibu olive (SO) consumption on cholesterol level and the development of atherosclerosis of mild hypercholesterolemia rabbits. A total of thirty five rabbits were randomly divided into 5 groups (n=7); NC (normal diet), PC (normal diet + 0.5% cholesterol), HS (hypercholestrolemic diet + 10 mg/kg/day simvastatin), HF (hypercholsterolemic diet + 5% fullfat SO) and HD group (hypercholesterolemic diet + 5% defatted SO). Main outcome measures were body weight changes, changes in total cholesterol, low-density lipoprotein cholesterol ( LDL-C), high-density lipoprotein cholesterol (HDL-C), and atherosclerotic plaque formation. After 8 weeks, there was increment in body weight changes (1.75–2.24 kg) of animals. The HD group showed significant reduction in total cholesterol (96.3%), LDL-C (26.5%) and HDL-C increment (46.8%) relative to PC. Futhermore, the atherosclerotic plaque formation in HD group diminished by 79.4% compared to PC. The polyphenols like phenolic acids, flavonoids, and anthocyanidins) that promote the lipid lowering potential of the SO fruit. Hence, in the future, SO fruit may serve as potent alternative treatment in the prevention of atherosclerosis.


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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Medicine and Health Science
Halal Products Research Institute
DOI Number: https://doi.org/10.1007/978-3-642-32183-2_37
Publisher: Springer Berlin Heidelberg (Springer Link)
Keywords: Sibu olive; Hypercholesterolemia; Rabbit, Artherosclerosis, Polyphenols
Depositing User: Azian Edawati Zakaria
Date Deposited: 27 Mar 2015 04:06
Last Modified: 27 Mar 2015 07:00
Altmetrics: http://link.springer.com/chapter/10.1007%2F978-3-642-32183-2_37
URI: http://psasir.upm.edu.my/id/eprint/33769
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