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Activin A: its role and involvement in inflammatory diseases


Tie, Tung Hing and Basir, Rusliza and Chuah, Yaw Kuang and Talib, Herni and Nordin, Norshariza (2015) Activin A: its role and involvement in inflammatory diseases. Pertanika Journal of Science & Technology, 23 (2). pp. 163-176. ISSN 0128-7680; ESSN: 2231-8526


Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types. Biologically active activins consist of homodimers or heterodimers of two beta (β) subunits that are linked together by a single covalent disulphide bond. The subunits in humans are βA, βB, βC and βE. As an example, a combination of two βA subunits will produce a unit of activin A. These proteins are found in most cells of body such as macrophage and activated circulating monocytes. Their role in inflammation can be categorised into two types, either pro- or anti-inflammatory agents, depending on the cell type and phase. Activin signals are kept in balance by antagonist follistatin (Fst), which is a glycoprotein expressed in tissues and encoded by the follistatin gene in humans.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Universiti Putra Malaysia Press
Keywords: Activin; Activin subunit; Follistatin; Inflammation; Transforming growth factor
Depositing User: Nabilah Mustapa
Date Deposited: 28 Aug 2015 06:41
Last Modified: 26 Jan 2016 04:32
URI: http://psasir.upm.edu.my/id/eprint/32562
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