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Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes


Citation

Jamil, Muhammad and Zubair, Muhammad and Farid, Muhammad Asim and Rashid, Umer and Rasool, Nasir and Islam, Saiful (2013) Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes. Journal of Chemistry, 2013. art. no. 789743. pp. 1-8. ISSN 2090-9063; ESSN: 2090-9071

Abstract

A series of some novel ,-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4 {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.


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Official URL or Download Paper: http://www.hindawi.com/journals/jchem/2013/789743/

Additional Metadata

Item Type: Article
Divisions: Institute of Advanced Technology
Faculty of Science
DOI Number: https://doi.org/10.1155/2013/789743
Publisher: Hindawi Publishing Corporation
Keywords: Thioureas; Antibacterial; Cytotoxic screening.
Depositing User: Azizan Arshad
Date Deposited: 20 Aug 2014 04:12
Last Modified: 05 Oct 2015 01:29
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/789743
URI: http://psasir.upm.edu.my/id/eprint/30814
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