UPM Institutional Repository

Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products


Citation

Gull, Yasmeen and Rasool, Nasir and Noreen, Mnaza and Nasim, Faiz-ul-Hassan and Yaqoob, Asma and Kousar, Shazia and Rashid, Umer and Bukhari, Iftikhar Hussain and Zubair, Muhammad and Islam, Md. Saiful (2013) Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products. Molecules, 18 (8). pp. 8845-8857. ISSN 1420-3049

Abstract

In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL.


Download File

[img]
Preview
PDF (Abstract)
Efficient synthesis of 2.pdf

Download (85kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Institute of Advanced Technology
Faculty of Science
DOI Number: https://doi.org/10.3390/molecules18088845
Publisher: Multidisciplinary Digital Publishing Institute
Keywords: Benzothiazoles; Nitric oxide scavenging activity; Suzuki cross coupling; Urease activity.
Depositing User: Azizan Arshad
Date Deposited: 20 Aug 2014 01:08
Last Modified: 20 Oct 2015 07:39
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules18088845
URI: http://psasir.upm.edu.my/id/eprint/30812
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item