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Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells


Citation

Shafie, Nurul Husna and Mohd Esa, Norhaizan and Ithnin, Hairuszah and Saad, Norazalina and Pandurangan, Ashok Kumar (2013) Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells. International Journal of Molecular Sciences, 14 (12). pp. 23545-23558. ISSN 1422-0067; ESSN:1422-0067

Abstract

Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a “natural cancer fighter”, being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. In addition, the up-regulation of caspase-3 and -8 expression and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells when exposed to IP6. Collectively, this present study has shown that rice bran IP6 induces apoptosis, by regulating the pro- and anti-apoptotic markers; Bax and Bcl-xl and via the activation of caspase molecules (caspase-3 and -8)


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Official URL or Download Paper: http://www.mdpi.com/1422-0067/14/12/23545

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/ijms141223545
Publisher: MDPI
Keywords: Inositol hexaphosphate; Rice bran; Apoptosis; Colorectal cancer
Depositing User: Umikalthom Abdullah
Date Deposited: 06 Apr 2015 01:46
Last Modified: 05 Feb 2016 02:21
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms141223545
URI: http://psasir.upm.edu.my/id/eprint/30728
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