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Synthesis of bisindolylmethanes and their cytotoxicity properties.


Mohan Naidu, Kalla Reddi and Khalivulla, Shaik Ibrahim and Syed Rasheed, and Fakurazi, Sharida and Arulselvan, Palanisamy and Lasekan, Olasegun and Abas, Faridah (2013) Synthesis of bisindolylmethanes and their cytotoxicity properties. International Journal of Molecular Sciences, 14 (1). pp. 1843-1853. ISSN 1422-0067


Polymer supported dichlorophosphate (PEG-OPOCl2) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.

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Official URL or Download Paper: http://www.mdpi.com/1422-0067/14/1/1843

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/ijms14011843
Publisher: MDPI Publishing
Keywords: Cytotoxicity properties; Bisindolylmethanes; Dibisindolylmethanes; Green catalyst.
Depositing User: Khairil Ridzuan Khahirullah
Date Deposited: 22 Aug 2014 00:54
Last Modified: 09 Oct 2015 00:38
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms14011843
URI: http://psasir.upm.edu.my/id/eprint/30448
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