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α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study


Citation

Sidahmed, Heyam M. A. and Abdelwahab, Siddig Ibrahim and Mohan, Syam and Abdulla, Mahmood Ameen and Elhassan Taha, Manal Mohamed and Mohd Hashim, Najihah and A. Hadi, A. Hamid and Vadivelu, Jamunarani and Loke, Mun Fai and Rahmani, Mawardi and Yahayu, Maizatulakmal (2013) α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study. Evidence-Based Complementary and Alternative Medicine, 2013. art. no. 450840. pp. 1-10. ISSN 1741-427X; ESSN: 1741-4288

Abstract

Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically guided fractionation of C. arborescens. Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol. Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated. The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro. AM (10 and 30 mg/kg) inhibited significantly (P < 0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively. The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity. The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti-H. pylori activity. The efficacy of the AM was accomplished safely without presenting any toxicological parameters. The results of the present study indicate that the antioxidant properties and the potent anti-H. pylori, in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α-mangostin.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1155/2013/450840
Publisher: Hindawi Publishing Corporation
Keywords: Cratoxylum arborescens; α-Mangostin; Gastroprotective activity; Mechanistic study.
Depositing User: Umikalthom Abdullah
Date Deposited: 03 Jul 2014 02:20
Last Modified: 05 Feb 2016 01:35
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/450840
URI: http://psasir.upm.edu.my/id/eprint/30158
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