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Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles


Citation

Al-Adiwish, Wedad M. and Mohamed Tahir, Mohamed Ibrahim and Adnan, Siti Noor Adnalizawati and Hashim, Siti Farah and Ibrahim, Nazlina and Yaacob, W. A. (2013) Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles. European Journal of Medicinal Chemistry, 64. pp. 464-476. ISSN 0223-5234

Abstract / Synopsis

New 5-aminopyrazoles 2a–c were prepared in high yields from the reaction of known α,α-dicyanoketene-N,S-acetals 1a–c with hydrazine hydrate under reflux in ethanol. These compounds were utilized as intermediates to synthesize pyrazolo[1,5-a]-pyrimidines 3a–c, 4a–d, 5a–c, and 6a–c, as well as pyrazolo[5,1-c][1,2,4]triazines 7a–c and 8a–c, by the reaction of 2-[bis(methylthio)methylene]malononitrile, α,α-dicyanoketene-N,S-acetals 1a–b, acetylacetone, acetoacetanilide as well as acetylacetone, and malononitrile, respectively. Furthermore, cyclization of 2a–c with pentan-2,5-dione yielded the corresponding 5-pyrrolylpyrazoles 9a–c. Moreover, fusion of 2a–c with acetic anhydride resulted in the corresponding 1-acetyl-1H-pyrazoles 10a–c. The antibacterial activity and cytotoxicity against Vero cells of several selected compounds are also reported.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/j.ejmech.2013.04.029
Publisher: Elsevier
Keywords: 5-Aminopyrazoles; Pyrazolo[1,5-a]pyrimidines; Pyrazolo[5,1-c][1,2,4]triazines; α,α-Dicyanoketene-S,S- and N,S-acetals; Antibacterial activity; Cytotoxicity.
Depositing User: Umikalthom Abdullah
Date Deposited: 30 Jun 2014 04:50
Last Modified: 30 Jun 2016 06:41
URI: http://psasir.upm.edu.my/id/eprint/30098
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