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Antileukemic properties of spermacoce species


Sukari, Mohd Aspollah and Utami, Rahayu and Neoh, Bee Keat and Ee, Gwendoline Cheng Lian and Jusoh, Shokri and Mohd Nor, Siti Mariam and Rahmani, Mawardi (2013) Antileukemic properties of spermacoce species. Asian Journal of Chemistry, 25 (8). pp. 4595-4598. ISSN 0970-7077


Antileukemic activity of th extracts and isolated compound from Spermacoce articularis, Spermacoce exilis and Spermacoce latifolia were carried out. All extracts of Spermacoce articularis as well as dichloromethane and ethyl acetate extracts of Spermacoce exilis showed strong activity against HL-60 cancer cell with IC50 value ranging from 0.4 to 7.2 μg/mL, whereas hexane extract of Spermacoce latifolia gave moderate activity with IC50 value of 13 ± 0.19 μg/mL. Ursolic acid as the major isolated constituent of these plants was found to have strong activity with IC50 of 1.3 ± 0.03 μg/mL against the same cancer cell.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Publisher: Chemic Publishing Company
Keywords: Spermacoce articularis; Spermacoce exilis; Spermacoce latifolia; Ursolic acid; Antileukemic.
Depositing User: Umikalthom Abdullah
Date Deposited: 18 Jun 2014 04:27
Last Modified: 03 Feb 2016 01:34
URI: http://psasir.upm.edu.my/id/eprint/30032
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