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A pH-sensitive, biobased calcium carbonate aragonite nanocrystal as a novel anticancer delivery system


Kamba, Abdullahi Shafiu and Ismail, Maznah and Tengku Ibrahim, Tengku Azmi and Abu Bakar @ Zakaria, Md Zuki (2013) A pH-sensitive, biobased calcium carbonate aragonite nanocrystal as a novel anticancer delivery system. BioMed Research International, 2013. art. no. 587451. pp. 1-10. ISSN 2314-6133; ESSN: 2314-6141


The synthesised biobased calcium carbonate nanocrystals had demonstrated to be an effective carrier for delivery of anticancer drug doxorubicin (DOX). The use of these nanocrystals displayed high levels of selectivity and specificity in achieving effective cancer cell death without nonspecific toxicity. These results confirmed that DOX was intercalated into calcium carbonate nanocrystals at high loading and encapsulation efficiency (4.8 and 96%, resp.). The CaCO₃/DOX nanocrystals are relatively stable at neutral pH (7.4), resulting in slow release, but the nanocrystals progressively dissociated in acidic pH (4.8) regimes, triggering faster release of DOX. The CaCO₃/DOX nanocrystals exhibited high uptake by MDA MB231 breast cancer cells and a promising potential delivery of DOX to target cells. In vitro chemosensitivity using MTT, modified neutral red/trypan blue assay, and LDH on MDA MB231 breast cancer cells revealed that CaCO₃/DOX nanocrystals are more sensitive and gave a greater reduction in cell growth than free DOX. Our findings suggest that CaCO₃ nanocrystals hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.

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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1155/2013/587451
Publisher: Hindawi Publishing Corporation
Keywords: Calcium carbonate; Nanocrystals; pH-sensitive; Drug delivery; Doxorubicin; Aragonite
Depositing User: Azizan Arshad
Date Deposited: 13 Nov 2014 02:52
Last Modified: 18 Nov 2016 07:50
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/587451
URI: http://psasir.upm.edu.my/id/eprint/29878
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