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Diuretic activity of roots from Carica papaya L. and Ananas comosus L.


Adam, Yunus and Abdul Aziz, Nasaruddin and Ahmad, Zuraini and Abd. Kadir, Arifah and Omar Fauzee, Mohd Sofian and Zakaria, Zainul Amiruddin and Somchit, Muhammad Nazrul (2013) Diuretic activity of roots from Carica papaya L. and Ananas comosus L. International Journal of Pharmaceutical Sciences Review and Research, 23 (1). art. no. 32. pp. 163-167. ISSN 0976-044X


Water extracts of Carica papaya and Ananas comosus extracts were administered orally at doses of 5 and 10 mg/kg to Spraque Dawley rats. Two other groups were given commercial diuretics, furosemide and hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 hours. Blood was taken to determine the serum level of glucose, albumin, blood urea nitrogen (BUN) and creatinine. Both, C. papaya and A. comosus extracts exhibited moderate to potent diuretic activity. C. papaya extract increased the 4-hour urine volume when administered at both 5 and 10 mg/kg. A. comosus extracts increased urine volume only at 10 mg/kg dose. Na+ and Cl- elimination was unchanged for the whole period of study. However, the 4-hour urinary excretions of K+ were significantly increased for both plant extracts. Both plant extracts induced increment of serum BUN and creatinine level significantly when compared to controls (p<0.05) but these levels were still within the normal range. Blood glucose level and albumin were not significantly for both plant extract. In conclusion, both plants investigated had diuretic activity and roots of C. papaya activity were statistically similar potency to the activity of furosemide and hydrochlorothiazide. However, care must be taken when using these herbs as increased urinary K+ being excreted and marginal increase of serum BUN and creatinine were detected.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Halal Products Research Institute
Sport Academy
Publisher: Global Research Online Publishing House
Keywords: Ananas comosus; Carica papaya; Electrolytes; Word diuretic
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 08 Dec 2014 01:14
Last Modified: 27 Oct 2015 06:13
URI: http://psasir.upm.edu.my/id/eprint/29830
Statistic Details: View Download Statistic

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