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The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways


Citation

Chien, Ing Yeo and Kah, Kooi Ooi and Md. Akim, Abdah and Ang, Kok Pian and Fairuz, Zainal Abidin and Abdul Halim, Siti Nadiah and Ng, Seik Weng and Seng, Hoi Ling and Tiekink, Edward R.T. (2013) The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways. Journal of Inorganic Biochemistry, 127. pp. 24-38. ISSN 0162-0134; ESSN: 1873-3344

Abstract / Synopsis

The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis is demonstrated and both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. Compound1 activates the p73 gene, whereas each of2 and3 activates the p53 gene. An additional apoptotic mechanism is exhibited by2, that is, via the JNK/MAP pathway.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1016/j.jinorgbio.2013.05.011
Publisher: Elsevier
Keywords: Phosphinegold(I) compounds; Carbonimidothioate; Thiolate; Apoptosis; Cancer; Cell cycle
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 27 Dec 2014 19:51
Last Modified: 08 Sep 2015 12:17
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.jinorgbio.2013.05.011
URI: http://psasir.upm.edu.my/id/eprint/29788
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