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An overview of in vitro research models for Alzheimer`s disease (AD)


Makena Ntimi, Carolindah and Rosli, Rozita and Adam, Aishah and Nordin, Norshariza (2013) An overview of in vitro research models for Alzheimer`s disease (AD). Regenerative Research, 2 (2). pp. 8-13. ISSN 2232-0822


Alzheimer’s disease (AD) is the most common form of age-related dementia. It is a neurodegenerative disease characterized by two aberrant features, the amyloid plaques and the neurofibrillary tangles which result in progressive memory loss and cognitive disturbances. This has led to devastating suffering to the patient, caregivers, family and economy of the country. As a result, scientists are putting efforts in understanding the mechanisms underlying the development of the disease as well as treatment for the disease. To do so, an ideal model is required that can mimic the development of AD,demonstrating the progressive degeneration of the neurons and formation of amyloid plaques and neurofibrillary tangles. In this review paper, currently available in vitro models for AD will be disc ussed, which include the cancer, primary culture and stem cell lines, highlighting on the benefits and limitations of each. More attention will be focused on the latest established disease-specific induced pluripotent stem cells (iPSCs)isolated from familial AD patients and Dow n syndrome patients. These models have their own advantages and limitations, therefore, more research needs to be done to come up with a model that is suitable not only for fundamental understanding of the disease but also for drug discovery and development.

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Official URL or Download Paper: http://regres.tesma.org.my/vol2-2.html

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Tissue Engineering and Regenerative Medicine Society of Malaysia
Keywords: Alzheimer`s disease; Cell lines; Genetics; In vitro models; Mechanisms; Neuroprotection; Pathogenesis
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 20 May 2015 08:26
Last Modified: 09 Oct 2015 06:53
URI: http://psasir.upm.edu.my/id/eprint/29707
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