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Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents


Citation

Mohd Moklas, Mohamad Aris and Suliman, Noor Azuin and Mat Taib, Che Norma and Baharuldin, Mohamad Taufik Hidayat and Fakurazi, Sharida and Zakaria, Fatin Nadzirah and Muhamamd Yusof, Muhammad Khairulasraf and Adzhar, Muhammad Farhan and Md Rasul, Mohd Saifuddin and Md Akim, Abdah and Amom, Zulkhairi (2013) Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents. Journal of US-China Medical Science, 10 (1-2). pp. 37-44. ISSN 1548-6648; ESSN: 1930-2088

Abstract

Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work. There are lack of information regarding to the effect of Mitragyna speciosa on cognitive and behavioural performances. Therefore the project was conducted to observe the effect of Mitragyna speciosa on cognitive behavior of rats and mice. Mitragyna speciosa in methanol extract form and aqueous extract form with same dosage distributions were used; 10 mg/kg, 30 mg/kg, and 100 mg/kg. Four tests were conducted to observe the behavioural changes of the animal namely locomotor, cognitive performances, anxiety and rotarod performance. Results showed that all dosage of treatment reduced locomotor and impaired cognitive performance significantly. Study showed that Mitragyna speciosa induce sedative effect in dose dependant manner. Interestingly, Mitragyna speciosa increased the time spent in open arm of plus maze indicating low anxiety level of the rodent. As conclusion, Mitragyna speciosa caused sedative effect, impairment in working memory, and possess anxiolytic properties.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: David Publishing
Keywords: Mitragyna speciosa; Mitragynine; Locomotor activity; Novel-object discrimination test; Anxiety
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 20 May 2015 08:09
Last Modified: 07 Oct 2015 08:30
URI: http://psasir.upm.edu.my/id/eprint/29705
Statistic Details: View Download Statistic

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