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Enhanced anti-inflammatory effects of nanoencapsulated diclofenac


Goh, Jun Zheng and Tang, Sook Nai and Ahmad, Zuraini and Zakaria, Zainul Amiruddin and Abdul Kadir, Arifah and Chiong, Hoe Siong and Omar Fauzee, Mohd Sofian and Abdullah, Muhammad Nazrul Hakim (2013) Enhanced anti-inflammatory effects of nanoencapsulated diclofenac. European Journal of Inflammation, 11 (3). pp. 855-861. ISSN 1721-727X


This study was conducted to compare the anti-inflammatory efficacy of nanoencapsulated and free-form diclofenac in rat. Diclofenac-loaded liposomes were prepared using the proliposome method. The anti-inflammatory effects of nanoencapsulated and free diclofenac were evaluated using the carrageenan-induced paw edema, formalin-induced paw licking and cotton-pellet-induced granuloma tests in vivo. For carrageenan-induced paw edema, 2 and 20 mg/kg liposome-encapsulated diclofenac showed significant paw volume reduction compared to free form diclofenac of equivalent dosage groups. In the formalin test, significant reduction in paw-licking time was observed in late phase for both liposome-encapsulated and free-form diclofenac (2 and 20 mg/kg) with the percentage of inhibition of 28.62, 60.17% for free-form diclofenac and 31.45, 78.84% for liposome-encapsulated diclofenac, respectively. In cotton-pellet-induced granuloma test 20 mg/kg free-form diclofenac showed significant reduction in the size of granuloma in both transudative and granuloma weight with percentage of inhibition of 42.93 and 49.26%, respectively, when compared to controls. Interestingly, 20 mg/kg nanoencapsulated diclofenac showed a larger reduction of the parameter with percentage of inhibition of 48.43 and 63.55%, respectively. Collectively, these results indicated that nanoencapsulated diclofenac exhibited statistically higher efficacy than free-form diclofenac when orally administered. Hence, clinical dosage may be reduced thereby reducing the drug's adverse effects.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Halal Products Research Institute
Sport Academy
DOI Number: https://doi.org/10.1177/1721727X1301100328
Publisher: Biolife
Keywords: Diclofenac; liposome; Efficacy and anti-inflammation; Nanoencapsulation
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 03 Aug 2016 03:37
Last Modified: 03 Aug 2016 03:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1177/1721727X1301100328
URI: http://psasir.upm.edu.my/id/eprint/29666
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