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Dietary non-nutritive factors on molecular targets of colorectal cancer: an update


Pandurangan, Ashok Kumar and Mohd Esa, Norhaizan (2013) Dietary non-nutritive factors on molecular targets of colorectal cancer: an update. Asian Pacific Journal of Cancer Prevention, 14 (10). pp. 5543-5552. ISSN 1513-7368


Colorectal cancer (CRC), a complex multi-step process involving progressive disruption of homeostatic mechanisms controlling intestinal epithelial proliferation/inflammation, differentiation, and programmed cell death, is the third most common malignant neoplasm worldwide. A number of promising targets such as inducible nitric acid (iNOS), cyclooxygenase (COX)-2, NF-E2-related factor 2 (Nrf2), Wnt/β-catenin, Notch and apoptotic signaling have been identified by researchers as useful targets to prevent or therapeutically inhibit colon cancer development. In this review article, we aimed to explore the current targets available to eliminate colon cancer with an update of dietary and non-nutritional compounds that could be of potential use for interaction with regulatory molecules to prevent CRC.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.7314/APJCP.2013.14.10.5543
Publisher: Asian Pacific Organization for Cancer Prevetion
Keywords: Colon cancer; COX-2; β-catenin; Nrf2; Notch
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 08 Dec 2015 00:44
Last Modified: 08 Dec 2015 00:44
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.7314/APJCP.2013.14.10.5543
URI: http://psasir.upm.edu.my/id/eprint/29617
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