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In vitro cytotoxic, antioxidant, and antimicrobial activities of Mesua beccariana (Baill.) Kosterm., Mesua ferrea Linn., and Mesua congestiflora extracts


Citation

Teh, Soek Sin and Ee, Gwendoline Cheng Lian and Mah, Siau Hui and Yong, Yoke Keong and Lim, Yang Mooi and Rahmani, Mawardi and Ahmad, Zuraini (2013) In vitro cytotoxic, antioxidant, and antimicrobial activities of Mesua beccariana (Baill.) Kosterm., Mesua ferrea Linn., and Mesua congestiflora extracts. BioMed Research International, 2013. art. no. 517072. pp. 1-9. ISSN 2314-6133; ESSN: 2314-6141

Abstract

The in vitro cytotoxicity tests on the extracts of Mesua beccariana, M. ferrea, and M. congestiflora against Raji, SNU-1, HeLa, LS-174T, NCI-H23, SK-MEL-28, Hep-G2, IMR-32, and K562 were achieved using MTT assay. The methanol extracts of Mesua beccariana showed its potency towards the proliferation of B-lymphoma cell (Raji). In addition, only the nonpolar to semipolar extracts (hexane to ethyl acetate) of the three Mesua species indicated cytotoxic effects on the tested panel of human cancer cell lines. Antioxidant assays were evaluated using DPPH scavenging radical assay and Folin-Ciocalteu method. The methanol extracts of M. beccariana and M. ferrea showed high antioxidant activities with low EC50 values of 12.70 and 9.77 μg/mL, respectively, which are comparable to that of ascorbic acid (EC50 = 5.62 μg/mL). Antibacterial tests were carried out using four Gram positive and four Gram negative bacteria on Mesua beccariana extracts. All the extracts showed negative results in the inhibition of Gram negative bacteria. Nevertheless, methanol extracts showed some activities against Gram positive bacteria which are Bacillus cereus, methicillin-sensitive Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA), while the hexane extract also contributed some activities towards Bacillus cereus.


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Official URL or Download Paper: http://www.hindawi.com/journals/bmri/2013/517072/

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1155/2013/517072
Publisher: Hindawi Publishing Corporation
Keywords: Vitro cytotoxic; Antioxidant; Antimicrobial activities; Mesua beccariana (Baill.) Kosterm.; Mesua ferrea Linn.; Mesua congestiflora
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 25 May 2015 05:10
Last Modified: 29 Dec 2015 04:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/517072
URI: http://psasir.upm.edu.my/id/eprint/29613
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