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MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome


Siew, Wei Hong and Tan, Kai Leng and Babaei, Maryam Abbaspour and Cheah, Pike See and Ling, King Hwa (2013) MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome. Frontiers in Cellular Neuroscience, 7. art. no. 41. pp. 1-13. ISSN 1662-5102


Intellectual disability (ID) is one of the many features manifested in various genetic syndromes leading to deficits in cognitive function among affected individuals. ID is a feature affected by polygenes and multiple environmental factors. It leads to a broad spectrum of affected clinical and behavioral characteristics among patients. Until now, the causative mechanism of ID is unknown and the progression of the condition is poorly understood. Advancement in technology and research had identified various genetic abnormalities and defects as the potential cause of ID. However, the link between these abnormalities with ID is remained inconclusive and the roles of many newly discovered genetic components such as non-coding RNAs have not been thoroughly investigated. In this review, we aim to consolidate and assimilate the latest development and findings on a class of small non-coding RNAs known as microRNAs (miRNAs) involvement in ID development and progression with special focus on Down syndrome (DS) and X-linked ID (XLID) [including Fragile X syndrome (FXS)].

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3389/fncel.2013.00041
Publisher: Frontiers
Keywords: Down syndrome; Brain development; Cognitive function; Fragile X syndrome; X-linked genetic disease; Non-coding RNA; Neuronal development; Mental retardation
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 18 Jan 2016 05:32
Last Modified: 28 Jan 2016 07:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3389/fncel.2013.00041
URI: http://psasir.upm.edu.my/id/eprint/29553
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