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Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves


Abd Hamid @ Abdul Razak, Roslida and Teoh, Hui Kee and Othman, Fezah (2013) Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves. Pharmacognosy Research, 5 (2). pp. 129-133. ISSN 0976-4836; ESSN: 0974-8490


Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods: Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used: Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results: Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions: Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.4103/0974-8490.110544
Publisher: Wolters Kluwer - Medknow Publications
Keywords: Acanthopanax trifoliatus; Anti-hyperalgesic carrageenan-evoked thermal hyperalgesia; Plantar test
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 08 Dec 2015 11:21
Last Modified: 31 Oct 2016 02:14
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4103/0974-8490.110544
URI: http://psasir.upm.edu.my/id/eprint/29530
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