UPM Institutional Repository

The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.


Citation

Julyantoro Pande, Gde Sasmita and Mohd Ikhsan, Natrah Fatin and Sorgeloos, Patrick and Bossier, Peter and Defoirdt, Tom (2013) The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Veterinary Microbiology, 167 (3-4). pp. 540-545. ISSN 0378-1135; ESSN: 1873-2542

Abstract

Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three channel quorum sensing system. Here we show that although they use a common signal transduction cascade, the signal molecules have a different impact on the virulence of the bacterium towards different hosts, i.e. the brine shrimp Artemia franciscana and the commercially important giant freshwater prawn Macrobrachium rosenbergii. These results suggest that the use of multiple types of signal molecules to regulate virulence gene expression is one of the features that allow bacteria to infect different hosts. Our findings emphasize that it is highly important to study the efficacy of quorum sensing inhibitors as novel biocontrol agents under conditions that are as close as possible to the clinical situation.


Download File

[img]
Preview
PDF (Abstract)
The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.pdf

Download (84kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Institute of Bioscience
DOI Number: https://doi.org/10.1016/j.vetmic.2013.08.021
Publisher: Elsevier
Keywords: Quorum sensing; Vibriosis; Host-microbe interaction; Host-pathogen interaction.
Depositing User: Norhazura Hamzah
Date Deposited: 08 Sep 2014 03:59
Last Modified: 05 Oct 2015 07:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.vetmic.2013.08.021
URI: http://psasir.upm.edu.my/id/eprint/29437
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item