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Antioxidant vitamins, oxidant injuries and diseases


Abba, Yusuf and Abu Hassim, Hasliza and Hamzah, Hazilawati and Mohamed Mustapha, Noordin (2015) Antioxidant vitamins, oxidant injuries and diseases. Pertanika Journal of Scholarly Research Reviews, 1 (1). pp. 58-66. ISSN 2462-2028


Over the past few decades antioxidant vitamins have been shown to aid in disease prophylaxis as well as treatment. Deficiencies of these vitamins in diets have resulted in associated deficiency syndromes in both humans and animals. Since a handful of disease conditions is associated with imbalances of antioxidant enzymes such as catalase, superoxide dismutase, glutathione as well as increases in reactive oxygen species (ROS), nitrogen oxide species (NOS) and lipid per-oxidation markers such as malondialdehyde, supplementation with antioxidant vitamins has resulted in amelioration of oxidative damage and ultimately disease recession. Vitamins A, C and E together with compounds such as carotenoids have been extensively studied for their roles in disease modulation or exacerbation. However, while Vitamins C and E have been shown to have immense potentials in the alleviation of several conditions, Vitamin A and especially carotenoids had shown little or no use in conditions such as cardiovascular disease and cancer prevention. This review highlights the documented roles of these vitamins in disease prevention over the past few decades and the potentials that need to be explored further.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: School of Graduate Studies, Universiti Putra Malaysia
Keywords: Antioxidant vitamins; Disease; Oxidative stress; Antioxidant enzymes
Depositing User: Nabilah Mustapa
Date Deposited: 07 Apr 2016 07:31
Last Modified: 04 Jul 2016 01:42
URI: http://psasir.upm.edu.my/id/eprint/28227
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