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The flavokawains: uprising medicinal chalcones


Abu, Nadiah and Ho, Wan Yong and Yeap, Swee Keong and Akhtar, Muhammad Nadeem and Abdullah, Mohd Puad and Omar, Abdul Rahman and Mohammed Alitheen, Noorjahan Banu (2013) The flavokawains: uprising medicinal chalcones. Cancer Cell International, 13 (1). art. no. 102. pp. 1-7. ISSN 1475-2867


Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
DOI Number: https://doi.org/10.1186/1475-2867-13-102
Publisher: BioMed Central
Keywords: Anti-cancer; Anti-inflammation; Apoptosis; Flavokawain; Kava-kava
Depositing User: Nabilah Mustapa
Date Deposited: 22 Apr 2016 03:04
Last Modified: 22 Apr 2016 03:04
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/1475-2867-13-102
URI: http://psasir.upm.edu.my/id/eprint/28086
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