UPM Institutional Repository

Zinc layered hydroxide-salicylate nanohybrid and its effect on Vero3 cells viability.


Ramli, Munirah and Hussein, Mohd Zobir and Mohd Yusoff, Khatijah Zinc layered hydroxide-salicylate nanohybrid and its effect on Vero3 cells viability. In: International Conference on "Nanotechnology Medicine", 7-9 Nov. 2012, London, United Kingdom. .


A new layered organic-inorganic nanohybrid based on zinc layered hydroxide (ZLH) which contains an anti-inflammatory agent, salicylate (SA) was synthesized through direct reaction of salicylic acid at various concentrations with commercially available zinc oxide (ZnO). Power x-ray diffraction (PXRD) patterns revealed that the basal spacing of the pure phase nanohybrid was 15.73 A. The SA anions were arranged in a vertical bilayer form, with the carboxylate functional groups pointing towards the inorganic layers of ZLH. Fouri er transform infrared (FTIR) spectrum for the synthesized nanohybrid illustrate ba'nds characteristic of salicylate and ZLH, thereby further confirming its intercalation into the interlayers of ZLH. The loading of SA in the nanohybrid was estimated to be around 29.7%, and the nanohybrid exhibited the properties of a mesoporous-type material. Thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the SA in the nanohybrid was greatly enhanced compared to its counterpart. In vitro cytotoxicity assay revealed that free SA, pure ZnO and the nanohybrid have mild effect on Viability of African green monkey kidney (Vero3) ceils.

Download File

[img] PDF
ID 27341.pdf
Restricted to Repository staff only

Download (55kB)

Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Science
Institute of Advanced Technology
Notes: Full text are available at Special Collection Division Office.
Keywords: Zinc layered hydroxide (ZLH); Zinc oxide (ZnO); Fourier transform infrared (FTIR); Vero3 cells; Anti-inflammatory agent; Salicylate (SA).
Depositing User: Samsida Samsudin
Date Deposited: 10 Mar 2014 06:31
Last Modified: 28 Aug 2014 02:06
URI: http://psasir.upm.edu.my/id/eprint/27341
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item