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Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.


Ismail, Intan Safinar and Low, K. W. (2012) Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques. In: 8th International Symposium on Chromatography of Natural Products, 17-20 May 2012, Lublin, Poland. .


Due to the lack of scientific investigation on Dysoxylum grande, chemical investigation on this plant icthyotoxic leaves was done. Thorough fractionation using various chromatographic techniques including High Performance Liquid Chromatography (HPLC) has led to the isolation and characterization of eight new triterpenoids. The new compounds were named as grandol A(1), B(2), C(3), D(4), E(5), F(6) and G(7)H. Another compound having a different configuration at C24 was assign as the new 20S, 24R0epoxy-7b, 25-dihydroxy-34-secodammar-4(28)-en-3-oic acid (8). All compounds were elucidated based on various spectroscopic data. Their relative configuration was established by 2D NMR data of NOESY. All compounds were tested for anti-acetylcholinesterase using Thin Layer Chromatography (TLC)-bioautography with fast blue B salt. Only grandol A91) and B(2) showed positive results with clear discoloration until at the concentration of 12.5 ppm. However, the obtained IC50 for both grandol A and B when using Ellman's method, was not significant (>200ug/ml) compared to galanthamine (1.955 ug/ml) or huperzine A (0.082 ug/ml[1,2]

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Institute of Bioscience
Notes: Full text are available at Special Collection Division Office
Keywords: Dysoxylum grande; Grandols; Chromatographic.
Depositing User: Erni Suraya Abdul Aziz
Date Deposited: 28 Feb 2014 12:52
Last Modified: 08 Apr 2014 09:22
URI: http://psasir.upm.edu.my/id/eprint/27331
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