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Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques.


Citation

Abdullah Al-Haj, Nagi Ahmed and Abdullah, Rasedee and Abdelwahab, Siddig Ibrahim and Abdul, Ahmad Bustamam (2008) Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. American Journal of Pharmacology and Toxicology, 3 (3). pp. 219-224. ISSN 1557-4962; ESSN: 1557-4970

Abstract

As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.3844/ajptsp.2008.219.224
Publisher: Science Publications
Keywords: Breast cancer; Cytotoxicity; Drug loading; High pressure homogenizatition; Solid lipid nanoparticles; Tamoxifen.
Depositing User: Azizan Arshad
Date Deposited: 08 Jan 2014 07:05
Last Modified: 07 Dec 2015 03:48
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3844/ajptsp.2008.219.224
URI: http://psasir.upm.edu.my/id/eprint/27056
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