Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.

Mitragyna speciosa is a species of tropical indigenous plant that can be found mainly in Southeast Asia. This study aims to ascertain the existence of antipyretic properties of the crude methanolic extract of Mitragynaspeciosa, and determine its effective dose against Brewer's yeast-induced pyrexia in mice. Thirty BALB/c mice were randomly divided into three treatment groups and two control groups. Pyrexia was induced by subcutaneous injection of 30% Brewer's yeast. Rectal temperature was recorded before and 18 h after induction of pyrexia every 30 min ofr 5 h. All groups treated with the crude methanolic extracts of Mitragynaspeciosa (50 mg/kg), 200 mg/kg were observed to produce signifivantreduction of rectal temperture as compared to the negative control group at different times. Ketoprofen at the dosage of 1 mg/kg coused significant (p<0.001) inhibition of fever from 0.5 to 5.0 h after treatment. In conclution, the crude methanolic extract of Mitragyna speciosa possessed dose-dependent antipyretic properties in mice. The antipyretic effective dose of the crude methanolic extract of Mitragyna speciosa was 100 mg/kg.

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