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Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart


Citation

Camalxaman, Siti Nazrina and Allaudin, Zeenathul Nazariah and Quah, Yi Wan and Loh, Hwei San and Hassan, Zuridah and Abdul Rahman, Sheikh Omar and Mohd Lila, Mohd Azmi (2011) Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart. Tropical Biomedicine, 28 (3). pp. 661-667. ISSN 0127-5720

Abstract

This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of a plausible immunological cross-reactivity between RCMV with its human counterpart which grounds substantial interest implying existence of conserved determinants between rat and human CMV polypeptides. The cross-reactive protein most likely represents an enveloped glycoprotein, though the precise identification and its degree of similarity needs to be evidently defined and further elucidated in forthcoming experiments.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Malaysian Society of Parasitology and Tropical Medicine
Keywords: Rat cytomegalovirus; Cross reactivity; Malaysian strain
Depositing User: Nur Farahin Ramli
Date Deposited: 22 Nov 2013 03:46
Last Modified: 30 Oct 2019 01:08
URI: http://psasir.upm.edu.my/id/eprint/25420
Statistic Details: View Download Statistic

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