UPM Institutional Repository

A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells.


Citation

Rajik, Mohamed and Omar, Abdul Rahman and Ideris, Aini and Syed Hassan, Sharifah and Yusoff , Khatijah (2009) A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells. International Journal of Biological Sciences, 5 (6). pp. 543-548. ISSN 1449-2288

Abstract

Avian influenza viruses (AIV), the causative agent of avian flu or bird flu, cause widespread morbidity and mortality in poultry. The symptoms of the disease range from mild flu like symptoms to death. These viruses possess two important surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA) against which neutralizing antibodies are pro-duced. Due to the highly mutative nature of the genes which encode these proteins, the vi-ruses often confer resistance to the current anti-viral drugs making the prevention and treatment of infection challenging. In our laboratory, we have recently identified a novel anti-viral peptide (P1) against the AIV H9N2 from a phage displayed peptide library. This peptide inhibits the replication of the virus in ovo and in vitro by its binding to the HA glyco-protein. In the current study, we demonstrate that the peptide inhibits the virus replication by preventing the attachment to the host cell but it does not have any effect on the viral fusion. The reduction in the viral nucleoprotein (NP) expression inside the host cell has also been observed during the peptide (P1) treatment. This novel peptide may have the potential to be developed as a therapeutic agent for the treatment and control of avian influenza virus H9N2 infections.


Download File

[img]
Preview
PDF (Abstract)
A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells.pdf

Download (84kB) | Preview
Official URL: http://ivyspring.com/

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Veterinary Medicine
Institute of Bioscience
Publisher: Ivyspring International Publisher
Keywords: Flow cytometry; Fluorescence microscopy; Influenza; Peptide inhibitors.
Depositing User: Nur Farahin Ramli
Date Deposited: 22 Oct 2013 04:47
Last Modified: 30 Oct 2015 01:49
URI: http://psasir.upm.edu.my/id/eprint/25348
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item