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Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II).


Citation

Tarafder, M.T.H. and Khoo, Teng Jin and Crouse, Karen Anne and Ali, A.M. and Yamin, B.M. and Fun, H.K. (2002) Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). Polyhedron, 21 (27). pp. 2691-2698. ISSN 0277-5387

Abstract / Synopsis

someric bidentate ligands having nitrogen–sulfur donor sequence were prepared by condensing S-benzyldithiocarbazate (SBDTC) with 5-methyl-2-furyladehyde (NS) and 2-furylmethylketone (NS′). Complexes of these ligands with lead, tin, iron, cobalt and cadmium gave complexes of [M(L)2] (M=Pb, Fe and Cd) and [M(L)2]Cln (M=Sn, n=2 and Co, n=1) (L=NS and NS′). The compounds have been characterized by spectroscopic studies (infrared, 1H NMR and electronic spectra). X-ray crystallographic analysis of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate shows the presence of two independent molecules in the asymmetric unit. The molecule adopts a trans–cis configuration, as was observed in other analogues, such as SBDTC where the furylmethylene and benzyl groups are trans and cis about the N-C and C-S bonds, respectively. The molecular structure of bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II) shows a tetrahedral geometry about the central cadmium atom with the bidentate ligand coordinating through the thioketo sulfur and the azomethine nitrogen atoms. The lead(II) complex of the NS ligand was highly cytotoxic against leukemic cells (CEM-SS) with a CD50 of 3.25 μg cm−3 while antimicrobial screening showed that the [Fe(NS)2]Cl2·H2O complex was effective against Aspergillus achraceous.


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Official URL: http://www.elsevier.com/

Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/S0277-5387(02)01272-X
Publisher: Elsevier
Keywords: Bioactivity; Cadmium(II) complexes; Crystal structures; Dithiocarbazate Schiff base crystal structures; Metal complexes; Schiff base ligands.
Depositing User: Nur Farahin Ramli
Date Deposited: 24 Jul 2013 10:56
Last Modified: 21 Jan 2016 12:05
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/S0277-5387(02)01272-X
URI: http://psasir.upm.edu.my/id/eprint/25095
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