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An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives.


Citation

Loo, Chew Hung and Basri, Mahiran and Tejo, Bimo Ario and Ismail, Rosnah and Lau, Harrison Lik Nang and Abu Hassan, Hazimah and Choo , Yuen May (2011) An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. Colloids and Surfaces B: Biointerfaces, 87 (1). pp. 180-186. ISSN 0927-7765; ESSN:1873-4367

Abstract

Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature high-pressure homogenisation technique involved in the preparation of NLCs can cause degradation of heat-sensitive compounds. Therefore, a novel preparation process needs to be developed to minimise the degradation of heat-sensitive active compounds during the preparation of NLCs. In this work, modified methods A and B were designed to minimise the degradation of β-carotene and tocols during the production of NLCs. These methods improved the chemical stability of heat-sensitive bioactive compounds (β-carotene and tocols) significantly compared to the previously established method. The physical stability of the formulation was maintained throughout study duration.


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Official URL: http://www.elsevier.com/

Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/j.colsurfb.2011.05.019
Publisher: Elsevier
Keywords: Improved method; Preparations; Nanostructured lipid carriers; Heat-sensitive bioactives.
Depositing User: Nur Farahin Ramli
Date Deposited: 16 Aug 2013 03:23
Last Modified: 05 Oct 2015 02:59
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.colsurfb.2011.05.019
URI: http://psasir.upm.edu.my/id/eprint/24950
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