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Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea.


Nugroho, Agung Endro and Anas, Yance and Arsito, Puguh Novi and Wibowo, Joko Tri and Riyanto, Sugeng and Md.Sukari, Mohd. Aspollah (2011) Effect of marmin, a compound isolated from aegle marmelos correa, on contraction of the guinea pig-isolated trachea. Pakistan Journal of Pharmaceutical Sciences, 24 (4). pp. 427-433. ISSN 1011-601X


Marmin or 7-(6',7'-dihydroxygeranyl-oxy)coumarin is a compound isolated from Aegle marmelos Correa. In the study, we examined the effects of marmin on the contraction of guinea pig-isolated trachea stimulated by several inducers, namely histamine, metacholine, compound 48/80. We also evaluated its action against contraction induced by extracellular or intracellular calcium ion. The possibility of marmin to potentiate the relaxation effect of isoprenaline was also studied. Marmin added in the organ bath at 10 min prior to the agonist inhibited the contraction elicited by histamine and metacholine in a concentration-dependent manner. Moreover, marmin antagonized the histamine-induced contraction in competitive manner. Marmin mildly potentiated the relaxation effect of isoprenaline. In the study, marmin abrogated the contraction of tracheal smooth muscle induced by compound 48/80, an inducer of histamine release. Besides, marmin successfully inhibited CaCl(2)-induced contraction in Ca(2+)-free Krebs solution. Marmin also inhibited two phases of contraction which were consecutively induced by metacholine and CaCl(2) in Ca(2+)-free Krebs solution. Based on the results we concluded that marmin could inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca(2+) release from the intracellular store and the Ca(2+) influx through voltage-dependent Ca(2+) channels.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Publisher: University of Karachi. Faculty of Pharmacy
Keywords: Marmin; Aegle Marmelos Correa; Guinea Pig-Isolated Trachea.
Depositing User: Nur Farahin Ramli
Date Deposited: 16 Aug 2013 02:50
Last Modified: 10 Dec 2015 02:05
URI: http://psasir.upm.edu.my/id/eprint/24949
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